FIG 8.

Rcs system influences the ability of S. marcescens to induce inflammation during corneal infection. (A to C) Median values and interquartile ranges for clinical signs of inflammation at 24 or 48 h after infection for conjunctiva (A) and cornea (B and C). The asterisks indicate significance by Kruskal-Wallis test with Dunn's posttest. (D) Enumeration of eyes with and without hypopyons. The asterisk indicates significantly fewer eyes with hypopyons than all other groups, except PBS, by Fisher's exact test. (E and F) Mean and standard deviation IL-1β cytokines per cornea and CFU per cornea; asterisks indicate differences by ANOVA with Tukey's posttest. For panel F, the asterisk indicates significantly fewer CFU per cornea than the other groups. n = 7 to 9 per group from a total of three independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.