TABLE 1.
GAS strains used in this study
| GAS strain | Description | Disease isolate sourcea | Reference or source |
|---|---|---|---|
| M1 (MGAS2221) | Representative serotype M1 isolate that naturally lacks RD2 | Scarlet fever | 9 |
| M1::RD2 (PGAS885) | MGAS2221 derivative in which RD2 has been introduced | NA | This work |
| M49 (591 and PGAS812) | Representative serotype M49 isolate that naturally lacks RD2 | Acute poststreptococcal glomerulonephritis | 9 |
| M49::RD2 (PGAS890) | 591 derivative in which RD2 has been introduced | NA | This work |
| M59 (MGAS15252 and PGAS535) | Representative serotype M59 isolate that naturally lacks RD2 | Soft tissue infection | 9 |
| M59::RD2 (PGAS891) | MGAS15252 derivative in which RD2 has been introduced | NA | This work |
| M28 (MGAS6180) | Representative serotype M28 isolate that naturally has RD2 | Invasive infection | 19 |
| M28::Spec | MGAS6180 derivative in which a spectinomycin resistance cassette replaced the aspA and M28_Spy1326 genes within RD2 | NA | This work |
a
NA, not applicable.