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. 2021 Jul 1;12:656115. doi: 10.3389/fphar.2021.656115

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Copyright © 2021 Wang, Tang, Zhao, Shen, Lin, Zhu and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SNS reverses activation of HSCs through modulating PPAR-γ and NF-κB p65. (A) Effects of SNS on protein levels of α-SMA, collagen I, fibronectin, p65 and PPARγ in activated LX2 cells. (B) Effects of SNS on mRNA levels of ACTA2, COL1A1, FN1, PPARG and RELA in activated LX2 cells. (C) Effects of SNS on MMP13 and TIMP1 mRNA levels in activated LX2 cells.