Table 2.

Loci of interest from genome-wide association study.

Number	Chr	Loci	Position	Nearest Gene	Other nearby gene	Minor allele	Major allele	Function	MAF			P a	OR (95%CI)
									Case	Control	Database (Chinese)
1	18	rs2847111	13501672	LDLRAD4		A	G	intronic	0.029	0.305	0.204	8.82E-07	0.069 (0.016-0.294)
2	18	rs3216103	13501276-13501280	LDLRAD4		TAG	DEL	intronic	0.059	0.331	0.277	3.91E-06	0.126 (0.044-0.366)
3	10	rs287187	77423073	KCNMA1		A	T	intronic	0.515	0.201	0.325	5.58E-06	4.208 (2.269-7.803)
4	12	rs1567584	51270520	SMAGP	BIN2	A	C	upstream	0.265	0.045	0.073	7.13E-06	7.560 (2.982-19.160)
5	7	rs2707521	121300382	CPED1	WNT16	T	C	intergenic	0.206	0.526	0.442	8.09E-06	0.234 (0.120-0.456)
6	7	rs2707520	121311090	CPED1	WNT16	A	C	intergenic	0.206	0.526	0.442	8.09E-06	0.234 (0.120-0.456)
7	1	rs11264505	156598460	GPATCH4		G	A	synonymous	0.162	0.013	0.092	5.38E-05	14.670 (3.153-68.210)
8	13	rs1047740	102796852	KDELC1		T	C	missense	0.279	0.546	0.481	2.58E-04	0.323 (0.174-0.599)
9	12	rs879732	12087265	BCL2L14		T	C	synonymous	0.735	0.474	0.495	3.99E-04	3.086 (1.650-5.747)
10	17	rs61644407	601889	VPS53		C	A	missense	0.427	0.195	0.257	4.98E-04	3.074 (1.646-5.739)
11	16	rs75559202	78425018	WWOX		G	C	missense	0.235	0.065	0.107	5.53E-04	4.431 (1.891-10.380)
12	7	rs73683127	18658043	HDAC9		T	G	splicing	0.324	0.123	0.141	6.70E-04	3.398 (1.689-6.837)
13	14	rs5510	94567019	SERPINA4		T	C	synonymous	0.132	0.351	0.325	6.89E-04	0.283 (0.130-0.614)
14	12	rs3210837	51292047	BIN2		T	C	synonymous	0.294	0.104	0.146	6.97E-04	3.594 (1.732-7.494)
15	19	rs306507	55947976	NLRP8		C	T	missense	0.074	0.260	0.170	1.04E-03	0.226 (0.085-0.602)
16	2	rs1044280	8731212	KIDINS220		A	C	missense	0.324	0.143	0.160	3.14E-03	2.870 (1.454-5.662)
17	5	rs1800449	122077513	LOX		T	C	missense	0.324	0.149	0.194	3.89E-03	2.724 (1.388-5.345)
18	14	rs2277484	24160535	RNF31		A	G	missense	0.324	0.149	0.112	3.89E-03	2.724 (1.388-5.345)
19	2	rs16831235	134987559	MAP3K19		A	G	missense	0.235	0.084	0.117	4.16E-03	3.337 (1.503-7.412)
20	7	rs2228410	36724067	AOAH		T	C	missense	0.647	0.435	0.500	5.46E-03	2.381 (1.319-4.297)
21	5	rs2455230	76637140	IQGAP2		C	G	missense	0.368	0.578	0.471	5.46E-03	0.425 (0.236-0.764)
22	18	rs2919643	45839038	SIGLEC15		C	T	missense	0.221	0.416	0.379	6.04E-03	0.398 (0.206-0.768)
23	17	rs17854914	4818081	PLD2		G	A	missense	0.000	0.097	0.049	6.51E-03	—
24	11	rs3816921	12224686	MICAL2		G	C	synonymous	0.235	0.429	0.456	6.59E-03	0.410 (0.215-0.782)
25	6	rs2523855	31054381	HCG22		C	G	missense	0.544	0.344	0.442	7.38E-03	2.274 (1.271-4.069)
26	6	rs2180314	52752933	GSTA2		C	G	missense	0.338	0.169	0.291	7.97E-03	2.516 (1.306-4.848)
27	20	rs2281929	63790727	ZBTB46		C	T	missense	0.338	0.533	0.447	8.72E-03	0.449 (0.248-0.813)
28	16	rs78108426	10907564	CIITA		A	C	missense	0.044	0.175	0.121	9.46E-03	0.217 (0.063-0.743)
29	3	rs3772173	170360444	SKIL		C	T	missense	0.265	0.117	0.194	9.48E-03	2.720 (1.312-5.640)

^aFisher exact test. Chr, chromosome; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval.