Table 4.
Multivariate logistic regression analysis of 9 SNPs from published studies.
| Reference | Gene | SNPs | Function | Genetic Model | Genotype | P | OR (95%CI) |
|---|---|---|---|---|---|---|---|
| Cummins NW et al. (16) | HMOX1 | rs743811 | 2.8kb 3’ of HMOX1 | Dominant | CC | 1.00 | |
| CT+TT | 0.505 | 1.122 (0.800-1.572) | |||||
| HMOX2 | rs2160567 | intronic | Overdominant | TT+CC | 1.00 | ||
| TC | 0.957 | 1.009 (0.722-1.412) | |||||
| Poland GA et al. (6) | IL-6 | rs1800796 | 5’-UTR | Dominant | CC | 1.00 | |
| CG+GG | 0.167 | 1.268 (0.905-1.776) | |||||
| IL-12B | rs3212227 | 3’-UTR | Dominant | TT | 1.00 | ||
| TG+GG | 0.016 | 1.614 (1.093-2.385) | |||||
| IL-1R1 | rs3732131 | 3’-UTR | Dominant | AA | 1.00 | ||
| AG+GG | 0.014 | 0.644 (0.454-0.913) | |||||
| IL-10RB | rs3171425 | 3’-UTR | Overdominant | GG+AA | 1.00 | ||
| GA | 0.490 | 1.127 (0.803-1.581) | |||||
| IL-10RA | rs4252249 | synonymous | Overdominant | GG+AA | 1.00 | ||
| GA | 0.179 | 1.449 (0.843-2.489) | |||||
| IL-1RN | rs315952 | synonymous | Dominant | CC | 1.00 | ||
| CT+TT | 0.112 | 0.753 (0.531-1.068) | |||||
| Egli A et al. (8) | IL-28B | rs8099917 | 7.5kb 5’ of IL28B | Overdominant | TT+GG | 1.00 | |
| TG | 0.323 | 1.334 (0.753-2.363) |
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.