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. 2021 Jul 6;24(3):637. doi: 10.3892/mmr.2021.12276

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Copyright: © Zheng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Effect of LDHA-knockdown on metabolism of Ishikawa cells and THESC cells. Histograms showing relative lactate expression in (A) Ishikawa cells and (B) THESC cells. LDHA-knockdown (sh-LDHA) significantly reduced lactate levels compared with their respective control groups (sh-Con). Protein expression levels of PDK1, a key enzyme in glycolysis, were determined by western blotting in (C) Ishikawa cells and (D) THESC cells. β-actin was used as a loading control. Values are expressed as mean ± SD of three independent experiments. Student's t-test was used to compare two groups. ***P<0.001 vs. sh-Con. LDHA, lactate dehydrogenase A; h-, short hairpin; Con, control; PDK1, pyruvate dehydrogenase kinase 1.