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. 2021 Jul 1;11:671431. doi: 10.3389/fonc.2021.671431

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Copyright © 2021 Nickson, Fabbrizi, Carter, Hughes, Kacperek, Hill and Parsons

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of USP9X in enhancing cellular radiosensitivity in response to high-LET α-particles and protons. HeLa cells were treated with USP9X siRNA (pool of 4 oligonucleotides) or a non-targeting (NT) control siRNA for 48 h and irradiated with increasing doses of (A, B) X-rays, (C, D) α-particles, (E, F) low-LET protons, or (G, H) relatively high-LET protons. Clonogenic survival of cells was analyzed from 2 independent experiments, and shown is the mean surviving fraction ± S.E. (B, D, F, H) Shown are representative images of colonies in non-irradiated and irradiated plates, the latter of which contained four times the number of cells seeded.