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. 2021 Jul 1;11:671431. doi: 10.3389/fonc.2021.671431

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Copyright © 2021 Nickson, Fabbrizi, Carter, Hughes, Kacperek, Hill and Parsons

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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USP9X depletion does not affect cellular levels of apoptosis, autophagy and senescence in response to relatively high-LET protons. HeLa cells were treated with USP9X or a non-targeting (NT) control siRNA for 48 h, and unirradiated (designated C) or irradiated with 4 Gy relatively high-LET or low-LET protons and allowed to repair for the time points indicated post-irradiation. (A, B, D) Whole cell extracts were analyzed by immunoblotting using the indicated antibodies. (C) Cells were fixed 48 h post-irradiation and stained for β-Galactosidase, with 100 µM H₂O₂ used as a positive control.