Table 1.
Candidate DUBs whose siRNA-mediated depletion enhance radiosensitivity of cells in response to α-particle radiation.
| DUB enzyme | α-particles | X-rays | High-LET protons | Low-LET protons |
|---|---|---|---|---|
| USP6 | 0.39 | 0.51* | 0.60 | 1.32 |
| USP21 | 0.41 | 0.52 | 1.06 | 0.82 |
| USP36 | 0.41 | 1.45 | 0.66 | 0.11 |
| DUB3 | 0.49 | 2.00 | 0.90 | 1.89 |
| STAMBPL1 | 0.52 | 0.67 | 0.72 | 0.31 |
| UCHL3 | 0.56 | 0.59 | 1.69 | 0.33 |
| AMSH | 0.57 | 0.37 | 1.47 | 1.59 |
| CYLD | 0.57 | 0.79 | 0.47 | 1.76 |
| UCHL5 | 0.57 | 0.64 | 1.51 | 0.54 |
| OTUB1 | 0.58 | 1.55 | 1.99 | 0.61 |
| USP9X | 0.80 | 0.90 | 0.60 | 1.50 |
Surviving fractions from a single experiment containing triplicate samples were normalized against the mock-treated control, which was set to 1.0. Survival data acquired in response to USP9X depletion is highlighted in bold. *Previously identified as a false positive result, data adapted from (7).