Table 2.
Candidate DUBs whose siRNA-mediated depletion enhance radiosensitivity of cells in response to high-LET protons.
| DUB enzyme | High-LET protons | Low-LET protons | α-particles | X-rays |
|---|---|---|---|---|
| CYLD | 0.47 | 1.76 | 0.57 | 0.79 |
| USP7 | 0.50 | 0.21 | 1.30 | 1.02 |
| USP31 | 0.59 | 0.38 | n.d. | n.d. |
| USP9X | 0.60 | 1.50 | 0.80 | 0.90 |
| USP6 | 0.60 | 1.32 | 0.39 | 0.51* |
| USP36 | 0.66 | 0.11 | 0.41 | 1.45 |
| USP39 | 0.67 | 0.04 | n.d. | 2.64 |
| STAMBPL1 | 0.72 | 0.31 | 0.52 | 0.67 |
| USP43 | 0.74 | 0.11 | n.d. | n.d. |
| YOD1 | 0.77 | 0.22 | 0.78 | 0.90 |
Surviving fractions from a single experiment containing triplicate samples were normalized against the mock-treated control, which was set to 1.0. n.d. indicates not determined. Survival data acquired in response to USP9X depletion is highlighted in bold. *Previously identified as a false positive result, data adapted from (7).