Table 4.
Multivariate analysis of risk factors associated with LRR.
| Variables | HR | 95% CI | P-value | |
|---|---|---|---|---|
| Age at diagnosis, years | >40 | 1 (reference) | 0.427 | |
| ≤40 | 1.214 | 0.752-1.959 | ||
| Pathological T stage | ypT0/ypTis | 1 (reference) | ||
| ypT1 | 1.888 | 0.367-9.708 | 0.447 | |
| ypT2 | 2.017 | 0.867-4.692 | 0.103 | |
| ypT3 | 1.857 | 0.806-4.278 | 0.146 | |
| Pathological nodal status | ypN- | 1 (reference) | 0.097 | |
| ypN+ | 1.589 | 0.920-2.745 | ||
| pCR | Yes | 1 (reference) | 0.452 | |
| No | 2.971 | 0.174-50.602 | ||
| Tumor grade | 1, 2 | 1 (reference) | 0.035 | |
| 3 | 1.738 | 1.038-2.908 | ||
| LVI | No | 1 (reference) | 0.035 | |
| Yes | 1.725 | 1.039-2.864 | ||
| Post-NACT Ki67 | <10% | 1 (reference) | 0.004 | |
| ≥10% | 2.208 | 1.295-3.765 |
CI, confidence interval; HR, hazard ratio; LRR, locoregional recurrence; LVI, lymphovascular invasion; NACT, neoadjuvant chemotherapy; pCR, pathological complete response.