Figure 5.

CIN attenuates inflammatory injury in M5-stimulated NHEKs. NHEKs were treated with CIN (5 or 10 µM) for 24 h, and then treated with 10 ng/ml M5 for 24 h. Reverse transcription-quantitative PCR was performed to measure the expression levels of (A) IL-1β, IL-8, (B) CXCL1, (C) S100A7, β-defensin2 and LL-37 in NHEKs. n=3. **P<0.01 vs. control group; ^#P<0.05, ^##P<0.01 vs. 10 ng/ml M5 group. CIN, cinnamaldehyde; NHEKs, normal human epidermal keratinocytes; CXCL1, C-X-C motif chemokine ligand 1; S100A7, S100 calcium binding protein A7; LL-37, cathelicidin antimicrobial peptide.