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. Author manuscript; available in PMC: 2021 Jul 15.
Published in final edited form as: J Med Chem. 2019 Sep 24;63(5):1779–1797. doi: 10.1021/acs.jmedchem.9b01105

Figure 1.

Figure 1.

Bivalent ligand cartoon with naltrexone (1), β-naltrexamine (2), norbinaltorphimine (3) and naltrindole (4). The bivalent ligand is represented while engaging in binding with GPCR monomer and homo/hetero-dimer.