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. 2021 Jul 15;28:53. doi: 10.1186/s12929-021-00749-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Cell apoptosis is inhibited by silenced NEAT1 or elevated miR-381 in ovarian granulosa cells from PCOS rats. A Apoptosis of ovarian granulosa cells from PCOS rats after transfection by flow cytometry; B Comparison of apoptosis rate of ovarian granulosa cells from PCOS rats after transfection; C Caspase-3 mRNA expression in ovarian granulosa cells from PCOS rats after transfection; D Bax mRNA expression in ovarian granulosa cells after transfection; E Bcl-2 mRNA expression in ovarian granulosa cells from PCOS rats after transfection; N = 3. The data are all measurement data, expressed as mean ± standard deviation, *P < 0.05 vs. the sh-NC group; #P < 0.05 vs. the mimic NC group, &P < 0.05 vs. the pc-NEAT1 + mimic NC group, and one-way ANOVA and Tukey’s post hoc test were used for statistical analysis