Body weight, brain weight and blood glucose at the basal state in the male (A-C) and female (D-F) 12-month-old mice. Unpaired t-test determined significant differences between CON and KO mice. A, Body weight, t statistic [df: 28]=0.8179, p-value=0.4203, n=15 each for CON and KO; B, Brain weight, t statistic [df: 25]=4.498, *p-value=0.0001, n=15 for CON and n=12 for KO; C, Blood glucose level, t statistic [df: 28]=0.8579, p-value=0.3982, n=15 each for CON and KO. D, Body weight, t statistic [df: 19]=2.818, *p-value=0.0110, n=11 for CON and n=10 for KO; E, Brain weight, t statistic [df: 18]=1.500, p-value=0.1510, n=10 each for CON and KO; F, Blood glucose level, t statistic [df: 19]=0.9147, p-value=0.3718, n=11 for CON and n=10 for KO