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. Author manuscript; available in PMC: 2021 Jul 15.
Published in final edited form as: Arch Pathol Lab Med. 2009 Mar;133(3):365–374. doi: 10.5858/133.3.365

Table 1.

Familial Aggregation Studies of Pancreatic Cancer

Study Design Study population Result (95% Confidence Interval) Referenc
e
Case-Control
Population-Based
 Quebec, Canada		 179 cases
179 controls		 OR=13 fold (p<.001)1 9
Case-Control
Hospital-Based
Northern Italy		 362 cases
1,408 controls		 OR=2.8 (1.3-6.3)2 91
Case Control
Hospital-Based
 Louisiana, USA		 363 cases
1,234 controls		 OR=5.25 (2.08-13.21)2 92
Case-Control
Population-Based
USA		 484 cases
2,099 controls		 OR=3.2 (1.8-5.6) 10
Case-Control
Population Based
 Southeastern MI,
USA		 247 cases
420 controls		 RR=2.49 (1.32-4.69)3 93
Case-Control
Hospital-Based
Texas, USA		 808 cases
808 matched controls		 OR=2.7 (1.7-4.3) 94
Nested Case-
Control
Japan		 200 cases
2000 matched controls		 2.09 (1.01-4.33) 95
Cohort
United States		 3,751 cases among
1,102,308 individuals
14 years of follow-up		 RR=1.5 (1.1-2.1)3 11
Cohort
Sweden		 21,000 cases among
10.2 million individuals		 RR=1.73 (1.13-2.54) 96
1

age, sex and language (French) matched

2

adjusted for tobacco, dietary factors and history of diabetes and pancreatitis, crude O R 3.0

3

adjusted for age, sex, ethnicity, ever smoking, proband ever smoking, diabetes, age of proband. 4 age-adjusted rate was equivalent