Table 2.
Genetic Syndrome | Gene(s) | Pancreatic cancer risk (fold) |
Histopathology |
---|---|---|---|
Hereditary breast and ovarian cancer
syndrome |
BRCA2 BRCA1 |
3.5-10 2 |
Ductal adenocarcinoma |
Peutz-Jegher syndrome | STK11/LKB1 | 132 | Intraductal papillary mucinous neoplasm |
Hereditary pancreatitis | PRSS1 SPINK1 |
53 | Ductal adenocarcinoma |
Hereditary non-polyposis colorectal cancer
syndrome |
Mismatch repair genes |
Increased | Medullary carcinoma |
Familial atypical multiple mole melanoma | CDKN2A | 13-22 | Ductal adenocarcinoma |
Familial adenomatous polyposis | APC | Up to 4 | Ductal adenocarcinoma Intraductal papillary mucinous neoplasm Pancreatoblastoma |
Familial Pancreatic Cancer | Unknown | 9-32 |