Table 1.
Baseline characteristics
| Variable | Total (N = 74) | ILDs (N = 36) | ILDd (N = 38) | P value |
|---|---|---|---|---|
| Age (years) | 59.47 ± 9.63 | 55.72 ± 9.94 | 63.00 ± 8.00 | 0.001 |
| Women, n (%) | 39.19% | 55.56% | 23.68% | 0.005 |
| Duration of disease (month) | 12 (2.8–48) | 6 (1–12) | 48 (12–72) | < 0.001 |
| ILD subtypes, n (%) | ||||
| IPF | 14 (18.9%) | 6 (16.7%) | 8 (21.1%) | |
| Unclassifiable ILD | 26 (35.1%) | 13 (36.1%) | 13 (34.2%) | |
| CTD-ILD | 23 (31.1%) | 10 (27.8%) | 13 (34.2%) | |
| Idiopathic NSIP | 6 (8.1%) | 3 (8.3%) | 3 (7.9%) | |
| HP | 5 (6.8%) | 4 (11.1%) | 1 (2.6%) | |
| SBP (mmHg) | 127.55 ± 14.81 | 129.33 ± 13.54 | 125.87 ± 15.91 | 0.318 |
| DBP (mmHg) | 77.77 ± 9.82 | 77.92 ± 9.21 | 77.63 ± 10.49 | 0.902 |
| PaO2 (mmHg) | 75.78 ± 16.04 | 79.64 ± 14.35 | 71.81 ± 16.91 | 0.039 |
| PaCO2 (mmHg) | 41.52 ± 7.37 | 41.5 (39.25–44.00) | 39.91 ± 5.68 | 0.092 |
| SaPO2 (%) | 96 (91–97) | 96 (94–97) | 95 (90–96) | 0.034 |
| NT-proBNP (pg/ml) | 50.56 (33.40–219.42) | 33.40 (23.74–47.96) | 125.00 (50.40–590.87) | < 0.001 |
| FVC% | 77.86 ± 18.81 | 83.89 ± 16.58 | 71.1 ± 19.16 | 0.012 |
| DLCO% | 51.74 ± 18.80 | 59.52 ± 16.71 | 43.06 ± 17.50 | 0.001 |
| TLC% | 70.52 ± 17.12 | 77.20 ± 17.19 | 63.04 ± 13.89 | 0.002 |
| ILD-GAP score | 2 (0–3) | 1 (-1–2) | 3 (1–4) | < 0.001 |
Data are presented as mean ± SD (normally distributed) or median [IQR] (not normally distributed)
ILD interstitial lung disease, IPF idiopathic pulmonary fibrosis, CTD connective tissue disease, NSIP nonspecific interstitial pneumonia, HP hypersensitivity pneumonitis, SBP systolic blood pressure, DBP diastolic blood pressure, PaO2 arterial oxygen partial pressure, PaCO2 arterial carbon dioxide partial pressure, SaPO2 arterial oxygen saturation, NT-proBNP N-terminal pro brain natriuretic peptide, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, TLC total lung capacity, GAP gender, age, physiology