Table 2.
Esculetin effect on myocardial lysosomal enzyme’s activity in ISO induced myocardial toxicity
| β-glucuronidase (p-nitro phenol/h/mg protein) | β-glucosidase (p-nitro phenol/h/mg protein) | β-galactosidase (p-nitro phenol/h/mg protein) | Acid phosphatase (p-nitro phenol/h/mg protein) | |
|---|---|---|---|---|
| Normal | 0.425 ± 0.003 | 0.050 ± 0.003 | 0.042 ± 0.004 | 0.071 ± 0.008 |
| Disease Control | 0.088 ± 0.007# | 0.114 ± 0.003# | 0.107 ± 0.007# | 0.159 ± 0.009# |
| Esculetin (10 mg/kg) | 0.536 ± 0.005* | 0.063 ± 0.005* | 0.073 ± 0.005* | 0.084 ± 0.005* |
| Esculetin (20 mg/kg) | 0.42 ± 0.001* | 0.06 ± 0.002* | 0.062 ± 0.001* | 0.079 ± 0.003* |
All values are shown as mean ± SEM and n = 6. Data analysis done by one way analysis of variance followed by the Tukey multiple comparison tests. # p < 0.05, indicate disease control compared with normal. * p < 0.05, indicate Esculetin compared with disease control group