Table 2.

Adjusted models: Cox model of mortality and Competing risks Regression models of ESKD and Death

Medication group	Cox model of Mortality HR (95% CI)* (N = 25,455, death events = 5562)	P-value	Competing Risks ESKD with death as competing risk SHR (95% CI)* (N = 25,455, ESKD events = 452, death events = 5362)	P-value	Competing Risks Death with ESKD as competing risk SHR (95% CI)* (N = 25,455, ESKD events = 452, death events = 5362)	P-value
PPI vs. none	0.97 (0.91, 1.03)	0.29	0.93 (0.75, 1.15)	0.49	0.96 (0.90, 1.02)	0.15
H2 vs. none	0.99 (0.86, 1.15)	0.90	1.07 (0.67, 1.73)	0.77	1.01 (0.87, 1.17)	0.95
PPI vs. H2	0.98 (0.84, 1.13)	0.77	0.87 (0.53, 1.42)	0.57	0.95 (0.82, 1.11)	0.53

*Adjusted for age, race, sex, eGFR, BMI group, hemoglobin, potassium, CO2, diabetes, hypertension, CVD, PVD,CAD, CHF, malignancy, ACE/ARB, beta blockers, smoking and insurance

All adjusted models used 5 datasets created with multiple imputation and MI analyze to obtain the HR or SHR