Fig. 7.

Schematic illustrations of NIR-mediated photothermal immunotherapy. A nanocomposite (FNPs/rGO-PEG) formulated by hybridizing Fe3O4 nanoparticles (FNPs), rGO and PEG-NH2 developed to destroy primary tumors was shown to elicit an anti-metastatic effect via photothermal immunotherapy. Under laser irradiation, FNPs/rGO-PEG nanocomposites generate heat and trigger immunogenic cell death (ICD). Then, the released tumor-associated antigens trigger the maturation of dendritic cells (DCs). DCs capture antigens and migrate to the tumor-draining lymph node to present antigens and activate T cells [166]. Reproduced by permission from the Royal Society of Chemistry