TABLE 1.
Clinical trials for TCM in treating CRC registered at ClinicalTrials.gov.
| Study title | Drugs involved | Status | Identifier |
|---|---|---|---|
| Strengthening the spleen and reducing phlegm Method in improving radical resection rate of colorectal cancer | Jianpi Huatan dispensing granule | Not recruiting, N/A | NCT03716063 |
| Huaier granule as adjuvant therapy for colorectal cancer after radical surgery | Huaier granule | Unknown, N/A | NCT02796820 |
| Simo decoction and acupuncture on POI in colorectal cancer | Simo decoction | Completed, phase 3 | NCT02813278 |
| Adjuvant chemotherapy combined with Huaier granule for treating high-risk stage II and stage III colorectal cancer | Huaier granule | Unknown, N/A | NCT02785146 |
| Fuzheng Yiliu-1010 | Fuzheng Yiliu formulation | Recruiting, phase 2 | NCT04459754 |
| Study of TCM syndrome of hepatocellular carcinoma and colorectal cancer based on system science | Bushen-Jianpi dedoction/Cinobufotalin injection | Recruiting, phase 1 | NCT03189992 |
| Pomegranate extract supplementation in colorectal cancer patients | Pomegranate extract | Completed, phase 1/2 | NCT01916239 |
| Effect of annona muricata leaves on colorectal cancer patients and colorectal cancer cells | Annona muricata extract | Completed, phase 1 | NCT02439580 |
| The efficacy of silymarin as adjuvant therapy on colorectal cancer patients undergoing FOLFIRI treatment | Silymarin | Completed, phase 4 | NCT03130634 |
| Does dietary nitrate supplementation improve aerobic performance | Beetroot juice | Not recruiting, phase 4 | NCT02319356 |
| Preventive strategies in colorectal carcinogenesis production and meat processing | Pomegranate extract | Completed, N/A | NCT02473302 |
| Gemcitabine combined with mistletoe in treating patients with advanced solid tumors | Mistletoe extract | Terminated, phase 1 | NCT00049608 |
| Genistein in the treatment of metastatic colorectal cancer | Genistein | Completed, phase 1/2 | NCT01985763 |
| Efficacy of ginseng for patients on regorafenib | Ginseng | Terminated (funder terminated) | NCT02581059 |
| Safety and effectiveness study of preoperative artesunate in stage II/III colorectal cancer (NeoART-V) | Artesunate | Recruiting, phase 2 | NCT03093129 |
| Avastin/FOLFIRI in combination with curcumin in colorectal cancer patients with unresectable metastasis | Curcumin | Completed, phase 2 | NCT02439385 |
| A pilot study of PPX in women with metastatic colorectal cancer | Paclitaxel Poliglumex | Completed, phase 1 | NCT00598247 |
| A safety and effectiveness study of preoperative artesunate in stage II/III colorectal cancer | Artesunate | Recruiting, phase 2 | NCT02633098 |
| Study of andrographolides with or without capecitabine to treat colorectal cancer | Andrographolides | Terminated (low accrual rate) | NCT01993472 |
| Effect of curcumin on dose-limiting toxicity and pharmacokinetics of irinotecan in patients with solid tumors | Curcumin | Completed, phase 1 | NCT01859858 |
| AZD2171 + chemotherapy in advanced NSCLC, colorectal cancer, or other cancers suitable for treatment with capecitabine (non-small-cell lung cancer patients closed to enrollment as 8/9/07) | Paclitaxel | Completed, phase 1 | NCT00107250 |
| Panitumumab skin toxicity prevention trial | Lycopene | Recruiting, phase 2 | NCT03167268 |
| Sulindac and plant compounds in preventing colon cancer | Curcumin/rutin/quercetin | Completed, N/A | NCT00003365 |
| Curcumin for the prevention of colon cancer | Curcumin | Completed, phase 1 | NCT00027495 |
| Combining curcumin with FOLFOX chemotherapy in patients with inoperable colorectal cancer | Curcumin | Completed, phase 1/2 | NCT01490996 |
| Resveratrol in treating patients with colorectal cancer that can be removed by surgery | Resveratrol | Completed, phase 1 | NCT00433576 |
| Cancer-associated thrombosis and isoquercetin (CATIQ) | Isoquercetin | Not recruiting | NCT02195232 |
| Preventive effect of enoxaparin, pentoxifylline, and ursodeoxycholic acid to radiation-induced liver toxicity | Ursodeoxycholic acid | Completed, phase 2 | NCT01149304 |
| Berberine chloride in preventing colorectal cancer in patients with ulcerative colitis in remission | Berberine chloride | Not recruiting | NCT02365480 |
| Paclitaxel and bortezomib in treating patients with metastatic or unresectable malignant solid tumors | Paclitaxel | Completed, phase 1 | NCT00667641 |
| Curcumin in combination with 5FU for colon cancer | Curcumin | Not recruiting | NCT02724202 |
| Study investigating the ability of plant exosomes to deliver curcumin to normal and colon cancer tissue | Curcumin | Not recruiting | NCT01294072 |
| Resveratrol for patients with colon cancer | Resveratrol | Completed, phase 1 | NCT00256334 |
| Phase III trial of gemcitabine, curcumin, and celebrex in patients with metastatic colon cancer | Curcumin | Unknown | NCT00295035 |
| Radiation therapy and capecitabine with or without curcumin before surgery in treating patients with rectal cancer | Curcumin | Not recruiting | NCT00745134 |
| Efficacy and safety evaluation of traditional Chinese medicine in the treatment of advanced colorectal cancer | Unknown | Not recruiting, N/A | NCT02923622 |
| Dietary bioflavonoid supplementation for the prevention of neoplasia recurrence | Flavonoids | Suspended, phase 2 | NCT00609310 |