Table 5.

Gene sets enriched in the high risk phenotype via GO

Gene set name	NES	NOM p-val	FDR q-val
GO_CHONDROCYTE_DIFFERENTIATION	2.459	< 0.001	< 0.001
GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT	2.444	< 0.001	< 0.001
GO_CHONDROCYTE_DEVELOPMENT	2.400	< 0.001	< 0.001
GO_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX	2.389	< 0.001	< 0.001
GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION	2.301	< 0.001	0.001
GO_EXTRACELLULAR_MATRIX_COMPONENT	2.264	< 0.001	0.002
GO_COLLAGEN_FIBRIL_ORGANIZATION	2.253	< 0.001	0.002
GO_COLLAGEN_BINDING	2.250	< 0.001	0.002
GO_COLLAGEN_TRIMER	2.241	0.002	0.003
GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT_CONFERRING_TENSILE_STRENGTH	2.222	< 0.001	0.003
GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	2.219	< 0.001	0.003
GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	2.175	< 0.001	0.005
GO_EXTRACELLULAR_MATRIX_BINDING	2.105	< 0.001	0.011
GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION	2.042	< 0.001	0.018
GO_ENDOTHELIAL_CELL_PROLIFERATION	1.990	0.002	0.024
GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION	1.942	0.002	0.031
GO_ENDOTHELIAL_CELL_MIGRATION	1.881	0.006	0.040
GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION	1.833	0.006	0.049
GO_FIBROBLAST_PROLIFERATION	1.801	0.006	0.056
GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION	1.770	0.011	0.063

Gene sets with NOM p-val < 0.05 and FDR q-val < 0.25 were considered significant

GO Gene Ontology, NES normalized enrichment score, NOM nominal, FDR false discovery rate