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. 2021 Jul 14;21:377. doi: 10.1186/s12935-021-02041-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — A Visualization of the protein–protein interaction (PPI) network as well as the hub genes module calculated by MCC algorithm. B Heatmap of hub genes expression in GSE12865. C Heatmap of hub genes expression in GSE14359. D Heatmap of hub genes expression in GSE33382. E Heatmap of hub genes expression in GSE36001. F Heatmap of hub genes expression in GSE99671