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. 2021 Jul 1;12:707404. doi: 10.3389/fimmu.2021.707404

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Copyright © 2021 Xia, Zhong, Zhao, Ren, Wang, Shi, Chai, Wang and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LTβR signaling and T cells regulate the development of eTPECs. (A) Flow cytometric analysis of TPEC and eTPECs in Ltbr ^fl/fl and Tek ^Cre Ltbr ^fl/fl mice. Left: Representative plots are shown. Right: Graphs display the statistical analysis of the percentage of TPECs or eTPECs. Mean ± SEM; n = 4. Data are representative of at least three independent experiments. (B) Flow cytometric analysis of TPEC and eTPECs in WT and Tcra ^−/− mice. Left: Representative plots are shown. Right: Graphs display the statistical analysis of the percentage of TPECs or eTPECs. Mean ± SEM; n = 3. Data are representative of two independent experiments. *P < 0.05; **P < 0.01 (unpaired Student’s t-test).