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. 2021 Jul 1;11:658552. doi: 10.3389/fonc.2021.658552

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Copyright © 2021 Cao, Zhang, Wang, Zhang, Zhou and Fang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic representation of cancer stem cells (CSCs) and their role in chemoresistance. The cancer stem cells (CSCs), not only enable tumor formation and progression but also mediate tumor metastasis and therapeutic resistance. On the one hand, the CSCs survived from chemotherapy will gain the chemoresistance and enhance the key processes involved in cancer progression. On the other hand, the cancer therapeutics targeted to CSCs biomarkers which can modulate EMT and CSC properties, can lead to the tumor shrinkage in clinical therapeutics.