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. 2021 Jul 1;11:710899. doi: 10.3389/fonc.2021.710899

Figure 2.

Figure 2

NPY, chromogranin, and (NPY, 400x) ERG expression and perineural invasion in prostate cancer. (A, B) Cytoplasmic-membranous NPY expression in neoplastic glands. (A) Strong expression score (2). (B) 200x Heterogenous intermediate NPY expression score and membranous apical immunostaining within the preexistent prostate glands (NPY, 200x). (C) Chromogranin – a strongly positive scattered single cell pattern (chromogranin, 400x). (D) A high level of neuroendocrine differentiation within PCa (chromogranin). (E) Nuclear ERG expression with diverse intensity within the cancer cells, positive endothelial cells, and immunonegative benign prostatic glands (ERG, 100x). (F) A histological section of prostate cancer with focal perineural invasion and other invisible neural components of the microenvironment (HE, 200x).