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. 2021 Jul 1;11:681530. doi: 10.3389/fonc.2021.681530

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Copyright © 2021 Fallah, Demas, Jin, He and Shajahan-Haq

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of WEE1 with AZD1775 increased G2/M cell cycle arrest in LTED cells. (A–D) MCF7 and T47D and their LTED derivatives were treated with vehicle, E2 deprivation (E2 dep), 500nM ribociclib (ribo), 500nM AZD1775, combination of E2 dep and ribo or the combination of E2 dep, ribo and AZD1775 for 6 days. Cell cycle profiles under different treatment conditions were analyzed by fluorescence-activated cell sorting (FACS) and compared to vehicle treated cells. Results are reported as mean percent cell cycle distribution + SE **p < 0.01 and ***p < 0.001 (ANOVA) for % cell in G2/M phase for indicated treatment conditions compared with vehicle control in respective cell lines. Bar graphs represent data from three independent experiments (n=3).