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. 2021 Jul 1;11:682461. doi: 10.3389/fonc.2021.682461

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Copyright © 2021 Gou, Hu, Liu, Dong, Gao, Wang, Zheng, Li and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PGK1 affected EMT process and glycolysis of ovarian cancer cells. (A) PGK1 protein expression in three kinds of ovarian cancer cell lines. (B) PGK1-siRNA inhibited the proliferation of ovarian cancer cells. (C) PGK1-siRNA reduced the formation of colonies of ovarian cancer cells. (D) PGK1-siRNA reduced the migration of ovarian cancer cells. (E) PGK1-siRNA reduced the invasion of ovarian cancer cells. (F) PGK1-siRNA decreased the protein expression levels of MMP2, MMP9, and N-cadherin but increased the protein expression level of E-cadherin. (G) Chart of ECAR measurement in PGK1-silenced cells. (H) Chart of OCR measurement in PGK1-silenced cells. Error bars represent the mean ± SD of three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001.