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Comparison of tumor oxygenation improvement strategies applied in cancer therapy.
| Strategies | Advantages | Disadvantages |
|---|---|---|
| Oxygen generation in situ | High tumor selectivity | Low amount of endogenous H2 O2 in tumor |
| Direct oxygen delivery | Simple and direct | Possible oxygen leakage during circulation |
| Improving blood flow | Endogenous O2 supply | Relative high phototoxicity Poor depth penetration |
| Decreasing oxygen consumption | Sustained | Limited oxygen enhancement effect |
