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. 2021 Jul 1;11:697409. doi: 10.3389/fonc.2021.697409

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Copyright © 2021 Dobre, Salvi, Pelisenco, Vasilescu, De Petro, Herlea and Milanesi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The graph shows the genes whose promoters methylation percentage were significantly higher in BRAF+ cases (n = 4) vs BRAF− cases (n = 14). The bars indicate the mean ± SEM. (B) Heat map of DNA promoter methylation according to mutation status. Methylation levels vary according to the color scale, ranging from light green (low) to red (high).