Table 5. Arterial blood pressure and doppler echocardiography measurements of dogs with B2 or C stages of myxomatous mitral valve disease supplemented or not with omega-3 for 12 months.
| Variables | Time | Treatments | p* | p** | |||
|---|---|---|---|---|---|---|---|
| n | Control | n | Omega-3 | ||||
| ABP (mmHg) | T0 | 13 | 137.64 ± 18.72 | 16 | 128.89 ± 20.52 | 0.316 | 0.800 |
| T3 | 10 | 140.47 ± 20.49 | 10 | 127.87 ± 26.62 | 0.393 | ||
| T6 | 9 | 142.03 ± 20.38 | 8 | 132.15 ± 15.72 | 0.370 | ||
| T9 | 9 | 138.53 ± 20.00 | 8 | 130.87 ± 27.05 | 0.541 | ||
| T12 | 7 | 138.28 ± 19.54 | 7 | 139.07 ± 19.53 | 1.000 | ||
| p*** | 0.993 | 0.911 | |||||
| LA (mm) | T0 | 13 | 29.44 ± 5.89 | 16 | 26.70 ± 5.84 | 0.316 | 0.900 |
| T3 | 10 | 24.88 ± 7.53 | 10 | 25.11 ± 6.91 | 1.000 | ||
| T6 | 9 | 21.97 ± 7.93 | 8 | 22.37 ± 7.80 | 1.000 | ||
| T9 | 9 | 20.32 ± 8.73 | 8 | 23.18 ± 7.52 | 0.541 | ||
| T12 | 7 | 20.41 ± 7.25 | 7 | 24.26 ± 6.52 | 0.423 | ||
| p*** | 0.060 | 0.479 | |||||
| Ao (mm) | T0 | 13 | 13.47 ± 2.03 | 16 | 12.34 ± 1.88 | 0.201 | 0.015 |
| T3 | 10 | 17.14 ± 8.53 | 10 | 11.93 ± 2.27 | 0.280 | ||
| T6 | 9 | 21.06 ± 10.32 | 8 | 13.85 ± 5.94 | 0.200 | ||
| T9 | 9 | 19.91 ± 10.31 | 8 | 13.21 ± 5.17 | 0.236 | ||
| T12 | 7 | 19.34 ± 10.29 | 7 | 15.86 ± 5.71 | 1.000 | ||
| p*** | 0.728 | 0.659 | |||||
| LA/Ao | T0 | 13 | 2.22 ± 0.49 | 16 | 2.20 ± 0.43 | 0.821 | 0.820 |
| T3 | 10 | 2.20 ± 0.44 | 10 | 2.12 ± 0.55 | 0.579 | ||
| T6 | 9 | 2.15 ± 0.55 | 8 | 1.98 ± 0.32 | 0.815 | ||
| T9 | 9 | 2.41 ± 0.49 | 8 | 2.12 ± 0.42 | 0.236 | ||
| T12 | 7 | 2.23 ± 0.47 | 7 | 2.00 ± 0.32 | 0.530 | ||
| p*** | 0.762 | 0.753 | |||||
| IVSs (mm) | T0 | 13 | 9.91 ± 1.55 | 16 | 8.45 ± 1.35 | 0.015 | 0.122 |
| T3 | 10 | 9.38 ± 1.57 | 10 | 8.14 ± 1.31 | 0.143 | ||
| T6 | 9 | 8.58 ± 2.05 | 8 | 7.73 ± 1.40 | 0.277 | ||
| T9 | 9 | 9.04 ± 1.97 | 8 | 8.25 ± 1.63 | 0.321 | ||
| T12 | 7 | 8.61 ± 2.00 | 7 | 9.20 ± 1.66 | 0.639 | ||
| p*** | 0.038 | 0.428 | |||||
| IVSd (mm) | T0 | 13 | 6.03 ± 1.38 | 16 | 5.38 ± 1.00 | 0.217 | 0.220 |
| T3 | 10 | 5.47 ± 0.96 | 10 | 5.00 ± 0.79 | 0.243 | ||
| T6 | 9 | 5.29 ± 1.15 | 8 | 5.21 ± 0.82 | 0.536 | ||
| T9 | 9 | 5.29 ± 1.23 | 8 | 5.33 ± 0.90 | 0.918 | ||
| T12 | 7 | 5.65 ± 0.86 | 7 | 6.53 ± 0.43 | 0.073 | ||
| p*** | 0.788 | 0.058 | |||||
| LVFWs (mm) | T0 | 13 | 10.21 ± 1.09 | 16 | 9.09 ± 1.34 | 0.043 | 0.273 |
| T3 | 10 | 10.08 ± 1.39 | 10 | 9.13 ± 1.70 | 0.113 | ||
| T6 | 9 | 9.55 ± 1.31 | 8 | 9.16 ± 1.18 | 0.606 | ||
| T9 | 9 | 9.89 ± 1.80 | 8 | 9.96 ± 1.93 | 0.837 | ||
| T12 | 7 | 10.47 ± 1.96 | 7 | 10.77 ± 1.41 | 0.755 | ||
| p*** | 0.770 | 0.254 | |||||
| LVFWd (mm) | T0 | 13 | 5.98 ± 0.97 | 16 | 5.39 ± 0.96 | 0.128 | 0.749 |
| T3 | 10 | 5.97 ± 1.17 | 10 | 5.21 ± 0.97 | 1.156 | ||
| T6 | 9 | 5.65 ± 1.09 | 8 | 5.70 ± 1.17 | 0.918 | ||
| T9 | 9 | 5.76 ± 1.38 | 8 | 5.68 ± 1.12 | 0.758 | ||
| T12 | 7 | 5.84 ± 0.96 | 7 | 6.24 ± 1.01 | 0.268 | ||
| p*** | 0.922 | 0.297 | |||||
| LVDN (mm) | T0 | 13 | 1.97 ± 0.41 | 16 | 1.95 ± 0.35 | 0.964 | 0.219 |
| T3 | 10 | 2.08 ± 0.45 | 10 | 1.90 ± 0.41 | 0.353 | ||
| T6 | 9 | 2.03 ± 0.37 | 8 | 1.67 ± 0.34 | 0.074 | ||
| T9 | 9 | 2.04 ± 0.46 | 8 | 1.62 ± 0.54 | 0.200 | ||
| T12 | 7 | 1.82 ± 0.41 | 7 | 1.66 ± 0.24 | 0.432 | ||
| p*** | 0.833 | 0.381 | |||||
| EF (%) | T0 | 13 | 79.36 ± 6.48 | 16 | 78.88 ± 6.99 | 0.981 | 0.679 |
| T3 | 10 | 79.00 ± 6.30 | 10 | 78.33 ± 6.94 | 0.720 | ||
| T6 | 9 | 76.11 ± 10.10 | 8 | 77.36 ± 5.72 | 0.918 | ||
| T9 | 9 | 73.52 ± 14.73 | 8 | 79.00 ± 8.89 | 0.470 | ||
| T12 | 7 | 71.38 ± 17.08 | 7 | 72.07 ± 17.60 | 1.000 | ||
| p*** | 0.643 | 0.958 | |||||
| SF (%) | T0 | 13 | 47.15 ± 6.34 | 46.83 ± 6.89 | 0.867 | 0.993 | |
| T3 | 10 | 47.10 ± 6.33 | 46.41 ± 6.69 | 0.780 | |||
| T6 | 9 | 44.37 ± 8.33 | 45.10 ± 5.64 | 0.918 | |||
| T9 | 9 | 45.19 ± 8.02 | 47.05 ± 7.76 | 0.536 | |||
| T12 | 7 | 44.43 ± 10.20 | 44.93 ± 11.52 | 0.876 | |||
| p*** | 0.720 | 0.948 | |||||
ABP: Arterial blood pressure; LA: Left atrium; Ao: Aorta; LA/Ao: Left atrium aorta ratio; IVSs: Interventricular septum in systole; IVSd: Interventricular septum in diastole; LVFWs: Left ventricular free wall thickness in systole; LVFWd: Left ventricular free wall thickness in diastole; LVDN: Normalized left ventricular diameter; EF: Ejection fraction; SF: Shortening fraction; p*: Differences within each time; p**: Differences in time and treatment interaction; p***: Difference between times within the treatments; Kruskal-Wallis test at 5% of significance.