Table 1. Single-omics analysis results for wildtype comparing 2% (H) and 0.05% (L) glucose.

First block shows GSEA for transcriptomics with adjusted p-value <0.05, arranged in ascending order; second block shows MetaboAnalystR pathway enrichment analysis for metabolomics with combined p-value <0.05 arranged in ascending order, as detailed in Methods. Enriched pathways refer to classifications provided in KEGG.

Transcriptomics				Metabolomics
enriched pathways	adjusted p-value	enriched pathways	adjusted p-value	enriched pathways	combined p-value
Ribosome	0.0023	Lysine biosynthesis	0.0051	Starch and sucrose metabolism	0.0010
Cell cycle—yeast	0.0023	Fructose and mannose metabolism	0.0075	Tyrosine metabolism	0.0065
Biosynthesis of amino acids	0.0023	Aminoacyl-tRNA biosynthesis	0.0080	Galactose metabolism	0.0073
RNA transport	0.0023	Sulfur metabolism	0.0094	Cysteine and methionine metabolism	0.0184
Ribosome biogenesis in eukaryotes	0.0023	One carbon pool by folate	0.0098	Glycolysis / Gluconeogenesis	0.0198
Cysteine and methionine metabolism	0.0023	Valine, leucine and isoleucine biosynthesis	0.0101	Inositol phosphate metabolism	0.0207
RNA polymerase	0.0023	Proteasome	0.0101	Amino sugar and nucleotide sugar metabolism	0.0233
Purine metabolism	0.0028	Autophagy—yeast	0.0184	Purine metabolism	0.0343
DNA replication	0.0028	Pyrimidine metabolism	0.0184	N-Glycan biosynthesis	0.0361
Galactose metabolism	0.0028	Amino sugar and nucleotide sugar metabolism	0.0188	Pentose phosphate pathway	0.0364
Glyoxylate and dicarboxylate metabolism	0.0028	Selenocompound metabolism	0.0226	Butanoate metabolism	0.0443
Citrate cycle (TCA cycle)	0.0028	Mismatch repair	0.0231
Peroxisome	0.0028	Glycine, serine and threonine metabolism	0.0322
Starch and sucrose metabolism	0.0028	Glycolysis / Gluconeogenesis	0.0387
Oxidative phosphorylation	0.0033	Autophagy—other	0.0416
Carbon metabolism	0.0041	Meiosis—yeast	0.0474