Table 5. Single- and Multi-omics integration results for asc1 by sensitivity analysis.

First block shows GSEA for transcriptomics with adjusted p-value <0.05, arranged in ascending order; second block shows MetaboAnalystR pathway enrichment analysis for metabolomics with combined p-value <0.05, arranged in ascending order; third block shows MetaboAnalystR joint pathway analysis with adjusted p-value <0.05, arranged in ascending order, as detailed in Methods.

Transcriptomics		Metabolomics		Integration
enriched pathways	adjusted p-value	enriched pathways	combined p-value	enriched pathways	adjusted p-value
Ribosome	0.0071	Lysine degradation	0.0082	Ribosome	4.76E-98
Ribosome biogenesis in eukaryotes	0.0071	Cysteine and methionine metabolism	0.0473	Ribosome biogenesis in eukaryotes	1.87E-21
Glyoxylate and dicarboxylate metabolism	0.0071			RNA polymerase	0.0015
RNA polymerase	0.0071			Galactose metabolism	0.0015
Peroxisome	0.0071			Pentose phosphate pathway	0.0422
Galactose metabolism	0.0104			Purine metabolism	0.0422
Citrate cycle (TCA cycle)	0.0141			Arginine biosynthesis	0.0422
RNA transport	0.0196
Starch and sucrose metabolism	0.0241
Carbon metabolism	0.0479
Propanoate metabolism	0.0479
Aminoacyl-tRNA biosynthesis	0.0498