Table 2.
Global spike protein mutations
| S. No | Country name | Total no of spike sequences | Mutations |
|---|---|---|---|
| 1 | USA | 2583 | L5H (3), L5F (20), L10I (2), N17K (1), C15F (1), L18F (6), T22A (1), T22I (2), A27S (1), A27V (2), T29I (1), S31F (1), H49Y (1), L54F (1), A67V (1), H69Y (1), G75V (1), D80N (1), V83F (1), V90F (1), S94F (1), T95I (1), S98F (3), V127F (1), G142V (1), V143D (1), V143F (1), Y145H (8), N148S (1), M153I (3), M153V (1), V159I (1), G181V (1), R190K (1),), R214L (1), D215Y (2), D215H (1), S221L (16), A243S (2), H245Y (1), H245R (1), D253G (1), G261A (1), A263V (1), E298G (1), E309Q (2),) T323I (2), A348S (1), S359N (1), V367F (1), P384L (1), P384S (2), V395I (1), A411S (1), A475V (1), N501Y (1), V503F (1), A520S (1), A522S (1), T553I (2), E554D (1), A570T (1), T572I (4), E583D (1), D614G (2,025), T618I (1), V622F (1), A623S (1), P631S (10), S640F (1), S640A (1), D645G (1),), A647S (2), A653S (1), H655Y (2), G652A (1), S659L (1), Q675H (1), Q675K (1), Q677H (1), T678I (1), N679K (1), S680F (1), P681L (1), R682W (1), S704P (1), A706V (1), S708F (1), N717T (1), M731I (2), T732I (1), D745G (1), L754F (1), G769V (1), T778I (1), E780V (1), P809S (1), P812L (3), D830G (1), A879S (1), G842S (1), A845S (2), A854S (1), T859I (8), A892S (1), A924V (1), G932D (1), S940F (1), T941I (1), D950H (1), S967R (1), T1027I (1), A1020S (1), M1050I (1), M1050V (1), A1078S (4), G1085R (5), H1101Y (5), D1118Y (1), V1133F (1), P1162L (1), D1163Y (1), V1176F (1), Q1180H (1), K1191N (1), N1194S (1), L1203F (2), K1205N (3), Q1208H (1), G1219C (1), G1219V (2), I1227M (1), V1228L (1), M1237T (5), M1237I (1), C1248F (1), S1252F (1) D1259H (1), P1263L (9) |
| 2 | Scotland | 1134 | M1C (1), F2L (1), L5F (5), L18F (2), R21I (3), P26S (1), A27S (1), T76I (1), V90F (4), T95I (1), E96D (1), V120F (1), G142A (3), H146Y (1), M153I (1), G181R (1), R190K (1), D198Y (1), L216F (1), H245Y (1), S247N (1), S254F (2), W258L (2), P272T (1), F338L (1), A344T (1), N354S (2), P384L (1), N439K (18), S477I (2), A522S (1), P588S (1), Q613H (1), D614G (847), A626S (1), A647S (1), H655Y (1), Y674F (1), A688V (1), I670M (4), Q675H (1), Q677H (1), A706V (1), G769V (3), P809S (1), A846V (1), A879S (7), A879T (5), S929T (2), S943I (2), T961M (1), T1077A (1), A1078V (1), P1079S (1), D1084Y (3), S1097T (1), H1101Y (1), W1102L (1), F1121L (8), G1124V (1), E1150D (1), P1162S (1), D1163Y (1), V1176F (2), K1191N (2), L1200F (6), H1201Y (1), E1207D (1), G1219V (2), V1228L (2), M1233I (1), C1248S (3), P1263L (5) |
| 3 | China | 734 | P9S (1), F32I (1), F32V (1), H49Y (23), S50L (7), L54F (1), A67S (1), H69Y (1), F92L (1), S98F (1), W152R (1), M153T (1), M153T (1), I197V (1), Y200S (1), D215G (1), D215H (1), G261R (2), S247R (2), S254F (1), R273M (1), F275Y (1), L276I (1), E298K (1), K300N (1), T302L (1), T307I (11), N317D (1), N354D (2), S359N (1), D364Y (1), K378R (1), Q409E (1), A411S (1), C432F (1), G485R (1), Q498H (1), H519P (1), T553I (1), 558N (1), A570V (3), P579Q (1), D614G (43), V615L (1), Y636F (1), H655Y (1), S659L (2), R682Q (1), N703S (1), S750R (1), S750I (1), L752F (1), L752R (2), G769A (1), T778N (1), P812T (1), I818S (1), G838S (1), A846V (1), L849F (1), V860Q (1), L861K (1), E868K (1), M900I (1), S943P (3), L948R (1), V952F (1), N969S (1), F970S (1), V1040F (1), V1060F (2), D1084Y (6), G1093A (1), F1103L (1), V1104L (1), V1129L (1), I1130L (3), D1146E (1), T1160K (1), S1161P (1), P1162S (2), P1162L (1), I1216T (1), G1171V (1), V1177A (1), I1216T (1), G1219C (1), S1252F (2), E1262G (1) |
| 4 | Japan | 625 | L5F (3), S13I (2), S50L (1), T95I (1), I119V (1), G181V (1), V213L (5), R357K (1), S477G (1), Q613H (11), D614G (331), P681H (3), S691F (1), R765L (1), I805M (2), A829T (2), A879S (1), D950Y (1), A1020D (1), T1027I (1), P1079T (1), K1086R (1), E1182K (1), E1202A (1), K1205N (1), G1219V (4), V1228L (1), M1229I (7) |
| 5 | South Africa | 592 | M1I (1), L5F (1), L8F (3), V11F (1), L54F (1), H69Y (1), V70F (1), D80Y (1), T95I (1), N121T (1), W152R (1), W152L (1), S155T (1), N188I (1), D198G (1), R214L (2), S221L (2), A222V (1), A344S (1), S373L (1), P384S (2), P385L (1), G413E (1), Y453F (1), I468V (1), Y508H (1), K558R (1), F562Y (1), D614G (579), V622F (1), H625Q (1), A653V (7), H655Y (3), N658D (1), T673P (1), T676P (2), Q677H (1), A688V (24), G769V (6), T778I (1), E780Q (1), P809S (2), P812L (4), A846V (4), N914S (1), L938I (3), G946R (1), A1020S (1), N1074H (2), A1078S (8), E1202D (1), L1203F (1), M1237I (1), C1243F (1), L1244F (1), T1273S (1), D1260Y (3) |
| 6 | France | 556 | L5F (6), L8W (1), L54F (4), A93S (1), L118F (1), V120I (3), S151I (1), W152R (1), M153I (1), V213L (1), T240I (1), L296H (1), V367F (5), C379F (1), V382E (1), Y508H (1), T553N (1), T572I (3), D574Y (1), L611F (1), D614G (517), A623S (1), S640F (1), A653V (1), T676I (3), S686G (1), S689I (1), I720V (1), R765L (1), N801K (1), P812L (1), A845V (1), A845S (9), A924S (1), D936Y (1), S939F (1), S940F (1), A1020V (1), L1063F (1), V1104L (1), I1132V (1), P1143L (2), P1162A (1), P1162L (3), G1219V (3), S1242I (1), D1260N (1), P1263L (1) |
| 7 | India | 542 | F2L (1), L5F (3), L7I (1), L18F (1), T22I (3), Y28H (2), H49Y (1), L54F (5), K77M (11), R78M (10), P82L (1), E156D (1), S162I (1), M177I (2), E224G (1), A243S (2), G261S (4), Q271R (2), T274I (2), D290Y (1), T299I (1), I402L (1), E471Q (1), A520S (6), S494P (1), K558N (2), T572I (4), D574H (1), E583D (7), T602I (1), D614G (179), R634S (1), Q677H (2), A706S (2), T323I (1), L828P (1), A831S (1), A930T (1), S1021F (1), T1027I (1), H1101Y (1), V1104L (1), G1124V (3), D1163F (1), I1179N (1), K1191N (1), C1243F (1), C1250F (1), G1251V (6), P1263L (1), M731R (1), T761S (1), G769V (1), A771V (1), F797C (1), G857C (1), A879S (1), A892V (1), V1068F (1) |
| 8 | Spain | 462 | V6I (1), T20S (1), P25S (1), F32Y (1), G75D (1), T95I (1), S98F (1), R102I (1), N125H (1), N148K (1), N149H (1), Q183L (1), I197V (5), D198G(1), V213L (1), A222V (1), H245Y (1), S254F (1), V483F (3), S594P (1), D614G (276), A623V (1), Q675R (1), A684V (1), I788M (1), T791K (1), Y837L (1), G838V (1), L841I (1), A871S (1), Q935H (1), Q954K (1), A1020S (1), V1068A (1), V1094F (1), T1120I (1), G1124 (3), G1167V (1) G1219C (1), G1219V (1), M1229I (1), D1259Y (1), L1265P (1) |
| 9 | Germany | 339 | S13I (1), T22I (1), T29I (1), S49L (2), S50L (1), T95I (1), S254F (2), K417N (2), K558R (2), T573I (1), D614G (292), V620I (2), E780Q (1), S789I (1), P809S (1), L938F (1), E990A (1), M1050V (1), D1162G (1), T1117I (1), K1191N (1) |
| 10 | Finland | 263 | L5F (4), A27S (1), G75V (1), S94F (1), D138H (1) Y144F (1), M153I (2), D215H (1), Q239K (1), A243P (1), L244F (1), L249S (1), A435S (1), G446V (1), D614G (253), H625R (5), Q675H (4), A684V (1), A688V (1), I692F (1), V860F (1), A879S (8), A899S (1), D936Y (179), L1063F (1), G1124C (1), V1133F (1), P1162L (1) |
| 11 | Russia | 240 | D614G (211), D261G (1), V193L (1), D198G (2) |
| 12 | Brazil | 220 | D164G (187), V1175F (4), K776T (1), L938F (1) |
| 13 | UK | 141 | L18F (1), R21I (1), V289I (1), D614G (84), A845S (1), A879S (1), I934M (1), D936Y (1), T1117I (1), V1133F (1), P1263L (5) |
| 14 | Italy | 128 | L5F (1), L216J (1), Q239K (1), L300J (1), A570D (2), D614G (120), N960B (1), T630S (1), D839Y (1) |
| 15 | Norway | 53 | L5F (3), V11I (1), A263S (1), G339D (1), Q613H (1), D614G (43), Q675H (1), A845T (1), A892S (1), D936Y (1), A1020V (3) |
| 16 | Australia | 48 | R78K (2), V445A (1), P491R (1), D614G (13), M731I (1), H1058Y (1) |
| 17 | Peru | 34 | L5F (1), I119V (8), D614G (29) |
| 18 | Mexico | 20 | H49Y (5), T573I (1), D614G (9), D1259Y (1) |
| 19 | Iran | 5 | T22I (3) |