Table 2.
Regional differences in gray matter volume between FED patients and healthy controls in the pooled meta-analysis.
| Brain regions | MNI coordinates | SDM value | p-value | Cluster | Jackknife sensitivity analysis | |||
|---|---|---|---|---|---|---|---|---|
| x | y | z | No. of voxels | Cluster breakdown (no. of voxels) | ||||
| FED<HC | ||||||||
| Left insula, BA 48 | −44 | 2 | −4 | −2.062 | 0.000020623 | 1,477 | Left insula, BA 38,45,47,48 (572) Left rolandic operculum, BA 48 (137) Left superior temporal gyrus, BA 21,22,38,48 (197) Left inferior frontal gyrus, opercular part, BA 6,44,48 (100) Left inferior frontal gyrus, triangular part, BA45,47,48 (58) Left inferior frontal gyrus, orbital part, BA38,47 (47) Left temporal pole, superior temporal gyrus, BA 21, 38, 48 (195) |
20/21 |
| Right parahippocampal gyrus, BA 30 | 24 | −30 | −14 | −1.956 | 0.000092924 | 690 | Right lingual gyrus, BA 27,30 (35) Right parahippocampal gyrus, BA 20,27,30,35,36,37 (126) Right hippocampus, BA20,30,35 (28) Right fusiform gyrus, BA 20,30 (48) Right cerebellum, hemispheric lobule III, BA 30 (29) Right cerebellum, hemispheric lobule IV/V, BA 30 (24) |
20/21 |
| Left parahippocampal gyrus, BA37 | −28 | −36 | −12 | −2.025 | 0.000046432 | 512 | Left parahippocampal gyrus, BA 20,30,37 (119) Left hippocampus, BA 20,30,37 (63) Left fusiform gyrus, BA30,37 (84) Left lingual gyrus, BA30,37 (15) |
20/21 |
| Right gyrus rectus, BA 11 | 8 | 22 | −18 | −1.968 | 0.000077426 | 383 | Right gyrus rectus, BA 11,25 (135) Right striatum (47) Right superior frontal gyrus, orbital part, BA 11,25 (21) |
19/21 |
| Right superior frontal gyrus, dorsolateral, BA 6 | 18 | 2 | 60 | −1.745 | 0.000381887 | 145 | Right superior frontal gyrus, dorsolateral, BA 6,8 (69) Right supplementary motor area, BA 6 (25) |
19/21 |
| Left superior frontal gyrus, medial, BA10 | −8 | 50 | 6 | −1.604 | 0.001068294 | 95 | Left superior frontal gyrus medial, BA10,32 (48) Left anterior cingulate / paracingulate gyri, BA10,32 (22) |
19/21 |
| Left superior parietal gyrus, BA7 | −30 | −70 | 56 | −1.603 | 0.001068294 | 55 | Left superior parietal gyrus, BA7 (54) | 19/21 |
FED, first-episode depression; HC, healthy control; MNI, Montreal Neurological Institute; SDM, signed differential mapping; BA, Brodmann area; FEW-corrected p < 0.05.