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. 2021 Jun 25;15:685703. doi: 10.3389/fncel.2021.685703

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Copyright © 2021 Boscia, Elkjaer, Illes and Kukley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The transcriptional landscape of ion channels in different types of white matter brain lesions from patients with secondary progressive multiple sclerosis. (A) The percentage of significantly differentially expressed genes coding for ion channels among all dysregulated genes and within each lesion type [chronic active (CA), active (AL), inactive (IL), and remyelinating (RL)] and normal-appearing white matter (NAWM) compared to control white matter are indicated. (B) The Venn diagram shows the number of lesion-specific differentially expressed genes coding for ion channels and the number of overlapping genes among the lesion types. (C) The number of significantly differentially upregulated (red) and downregulated (blue) genes in each type of while matter lesion and NAWM compared to control white matter are indicated.