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. 2021 Jun 25;15:685703. doi: 10.3389/fncel.2021.685703

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Copyright © 2021 Boscia, Elkjaer, Illes and Kukley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of uniquely dysregulated genes encoding ion channels in SPMS lesions. Schematic representation of active (AL), chronic active (CA), inactive (IL), and remyelinating (RL) lesions, and normal-appearing white matter (NAWM). Upregulated (blue) and downregulated (red) ion channels encoded by uniquely dysregulated genes are listed according to their expression in the lesions and in neuronal, oligodendrocyte precursor cells (OPCs), committed OPCs (COPs), oligodendrocytes (Oligo), microglia, immune oligo (ImOLG), astrocyte, pericyte, and unknown clusters. GM, gray matter; WM, white matter; v, brain ventricle. Gray areas indicate active inflammatory lesion, white areas indicate demyelinated inactive lesions, red spot indicates tissue damage, red arrow indicates axonal dysfunction. Source icon is from Biorender.com.