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Putative roles of ion channels encoded by uniquely dysregulated genes in SPMS lesions. Schematic illustration of the putative detrimental (red box), putative beneficial (blue box), and unexplored (gray box) functional roles of ion channel encoded by the uniquely dysregulated genes in active (AL), chronic active (CA), inactive (IL), and remyelinating (RL) lesions, and normal-appearing white matter (NAWM) of SPMS brain. Source icon is from Biorender.com.
