Figure 8.
Using a model of HCN channels including a shunting current in model 1 produces realistic impedance amplitude and phase response, comparable with model 5. A: morphologies of model 1 and model 5. B: distribution of gIh, which affects both Ih and TASK-like shunting current, in the two models. Distances are normalized to the farthest compartment from the soma in each cell. C: transfer frequencies increase but remain within experimental range as originally. D: synchronous frequencies along the apical trunk are greatly improved compared to the experimental data (red). *Experimental values for transfer and synchronous frequencies. E: total inductive phase between model 5 and the adjusted model 1 are similar. Note that distances in C–E are normalized to the length of each model’s apical trunk. HCN, hyperpolarization-activated cyclic nucleotide-gated; Ih, h-current; TASK, Twik-related acid-sensitive K+.