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A proposed mechanism that OX1R activation on sympathetic nerve activity and blood pressure regulation. Binding of orexin-A with OX1R results in OX1R activation, which in turn triggers the influx of Ca2+ resulting in intracellular Ca2+ increase. Ca2+, in turn, activates CaMKII enzyme activity as well as CaMKII expression, which eventually results in SNA increase and blood pressure elevation.
