FIGURE 1.

Dioscin protects cardiac function in mouse model of myocardial infarction. 8 weeks old mice were intragastric administrated with Vehicle (Veh) or Dioscin (Dio) for 2 weeks after myocardial infarction (n = 6 each group). (a) Representative echocardiogram of the cardiac function of mice (M‐mode, parasternal short axis) for each condition. (b) Quantification of left ventricular ejection fraction (LVEF, %) and left ventricular fractional shortening (LVFS, %). (c) Quantification of left ventricular end‐diastolic internal dimension (LVEDD, mm) and left ventricular end‐systolic internal dimension (LVESD, mm). (d) Hematoxylin and eosin (H&E) staining (scale bar: 1mm) of heart sections from mice treated with Vehicle or Dioscin. (e,f) Ratios of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) were shown, respectively. (g) Real‐time PCR analysis of the messenger RNA (mRNA) expression of Anp, Bnp, and β‐Mhc was performed using heart tissues from Sham group and MI group treated with Vehicle or Dioscin. Data were presented as mean ± SEM. *p < 0.05 relative to Sham; #p < 0.05 relative to MI; &p < 0.05 relative to MI with 40 μg/g Dioscin