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. 2021 Jun 3;20(7):e13392. doi: 10.1111/acel.13392

FIGURE 5.

FIGURE 5

Dioscin enhances the complex formation between MANTIS and BRG1. (a) Chromatin Immunoprecipitation (CHIP) was performed to access the assembly of the MANTIS and BRG1 by Dioscin. (b) Real‐time reverse transcription (RT‐PCR) analysis was performed for SOX18 mRNA expression. (c) SMAD6 mRNA level was detected in Dioscin‐treated endothelial cells using real‐time PCR analysis. (d) Real‐time PCR analysis for COUP‐TFII mRNA expression. (e) Representative images of CD31 (red), BRG1 (green), and nucleus (blue) co‐staining in endothelial cells in heart tissue after Sham and MI group (scar bar: 50 um). (f) Schematic diagram showing the molecular signing pathway for Dioscin‐induced angiogenesis. *p < 0.05 relative to siScr; #p < 0.05 relative to Vehicle