TABLE 1.

Immunolabeling measures: Drug × Sex effects within genotype groups

	WT Veh	WT Q1	APP/PS1 Veh	APP/PS1 Q1
Aβ
M	‐‐	‐‐	0.38 ± 0.09	0.49 ± 0.14
F	‐‐	‐‐	0.92 ± 0.2 b	0.97 ± 0.22
GFAP
M	1.06 ± 0.16	0.92 ± 0.22	2.23 ± 0.28	1.60 ± 0.25
F	1.22 ± 0.29	1.73 ± 0.39	3.09 ± 0.40	3.14 ± 0.28 c
Iba1
M	1.43 ± 0.60	0.91 ± 0.35	2.22 ± 1.42	1.32 ± 0.42
F	1.26 ± 0.39	2.91 ± 1.16	2.74 ± 0.55	1.63 ± 0.58
NFAT4/GFAP
M	0.53 ± 0.06	0.40 ± 0.04	0.90 ± 0.14	0.8 ± 0.14
F	0.58 ± 0.10	0.78 ± 0.16 a	1.27 ± 0.17	0.94 ± 0.15
NFAT4/DAPI
M	0.67 ± 0.13	0.74 ± 0.24	1.24 ± 0.26	1.01 ± 0.20
F	0.96 ± 0.34	0.97 ± 0.28	1.46 ± 0.23	1.31 ± 0.23

All values are expressed as mean ± SEM labeling intensity (% area occupied). ns per group are indicated in text. Approximately 46% of mice were male.

^a vs. Male WT Q134R.

^b vs. Male APP/PS1 vehicle.

^c vs. Male APP/PS1 Q134R.