TABLE 2.

Electrophysiology measures: Drug × Sex effects within genotype groups

	WT Veh	WT Q1	APP/PS1 Veh	APP/PS1 Q1
Max EPSP/FV
M	4.10 ± 0.93	3.08 ± 0.66	2.38 ± 0.49	2.60 ± 0.57
F	2.25 ± 0.58 a	2.1 ± 0.35	1.61 ± 0.27	3.07 ± 0.46 b
PPF
M	161 ± 11	159 ± 12	161 ± 12	148 ± 10
F	155 ± 12	169 ± 6	150 ± 5	174 ± 10
PS Threshold
M	0.45 ± 0.10	0.37 ± 0.09	0.31 ± 0.07	0.27 ± 0.06
F	0.23 ± 0.03 a	0.41 ± 0.05	0.27 ± 0.04	0.37 ± 0.05
LTP
M	154 ± 8	152 ± 10	112 ± 12	167 ± 26c
F	141 ± 11	128 ± 8	132 ± 6	155 ± 14

All values are expressed as mean ± SEM. ns per group are indicated in text. Approximately 44% of mice were male.

^a vs. Male WT vehicle.

^b vs. Male WT Q134R.

^c vs. Male APP/PS1 vehicle.