Skip to main content
. 2021 Jun 5;20(7):e13411. doi: 10.1111/acel.13411

FIGURE 1.

FIGURE 1

Myogenic capacity of human MuSCs is uncompromised despite aging. (a‐h) Human skeletal muscle regeneration following postmortem muscle tissue engraftment from human cadavers of various ages and PMIs. Immunostaining for human‐specific spectrin (SPEC, red), and lamin A/C (LMNA, green) proteins identify regions regenerated from dormant human MuSCs within the grafted tissue, while DAPI (blue) mark the entire muscle tissue section for reference (a, c, e, g). Human muscle regeneration shown here from transplanted human cadaver muscle at the indicated PMI; 58‐year‐old (a, b; male, psoas), 66‐year‐old (c, d; female, abdominal), 75‐year‐old (e, f; male, abdominal), and 78‐year‐old (g, h; male, rectus femoris). Histology of adjacent serial sections performed by H/E staining shows regrowth of both human and mouse muscle tissue (delineated by black dotted line) harvested from anterior tibial compartment 3‐week post‐engraftment (b, d, f, h). Scale bars represent 200 μm (a‐h).