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. 2021 Jun 23;20(7):e13409. doi: 10.1111/acel.13409

TABLE 1.

Seventy‐nine significant miRs comparing the four age groups

miRNA Young versus Old Young versus Healthy Centenarians Young versus Unhealthy Centenarians Old versus Healthy Centenarians Old versus Unhealthy Centenarians Healthy versus Unhealthy Centenarians
logFC p Value logFC p Value logFC p Value logFC p Value logFC p Value logFC p Value
hsa‐miR‐19b‐3p −0.45 0.44195 3.22 0.00000 0.74 0.20705 3.67 0.00000 1.19 0.04460 −2.47 0.00007
hsa‐miR‐19a‐3p −0.61 0.32607 2.72 0.00005 0.12 0.85258 3.32 0.00000 0.72 0.24727 −2.60 0.00010
hsa‐miR‐4433b‐3p −0.62 0.33335 0.12 0.85214 −2.10 0.00143 0.73 0.25130 −1.49 0.02113 −2.22 0.00083
hsa‐miR‐145‐5p −0.36 0.53771 1.06 0.07674 −0.87 0.14561 1.42 0.01820 −0.50 0.39550 −1.93 0.00168
hsa‐miR‐10b‐5p −0.23 0.67868 0.98 0.08227 −0.78 0.16622 1.21 0.03251 −0.55 0.32911 −1.76 0.00225
hsa‐miR‐6503‐3p 0.04 0.96595 3.80 0.01057 −0.76 0.50871 3.76 0.01061 −0.80 0.47532 −4.56 0.00318
hsa‐miR‐4485‐3p −2.65 0.00097 −4.27 3.88E−07 −2.08 0.01359 −1.62 0.02325 0.57 0.44840 2.19 0.00447
hsa‐miR‐887‐3p −0.63 0.45000 1.36 0.15532 −1.37 0.12395 2.00 0.03631 −0.74 0.39679 −2.73 0.00636
hsa‐miR‐598‐3p 0.48 0.48107 −0.10 0.88196 1.98 0.00975 −0.58 0.39502 1.50 0.04816 2.08 0.00679
hsa‐miR‐296‐5p −0.04 0.96455 1.85 0.04817 −0.80 0.35595 1.88 0.04359 −0.77 0.37654 −2.65 0.00705
hsa‐miR‐2277‐5p 1.12 0.34804 −1.25 0.30078 5.31 0.05158 −2.37 0.04967 4.19 0.14532 6.56 0.00969
hsa‐miR‐6842‐5p 2.54 0.04601 −0.89 0.44412 5.51 0.03971 −3.43 0.00821 2.97 0.33053 6.40 0.01190
hsa‐miR‐4739 2.19 0.22166 2.19 0.37088 −3.96 0.05106 0.00 1.00000 −6.14 0.00233 −6.14 0.01199
hsa‐miR‐122‐5p −1.02 0.07037 0.14 0.80639 1.52 0.00788 1.15 0.04072 2.53 0.00002 1.38 0.01525
hsa‐miR‐31‐5p −1.88 0.02831 0.97 0.29556 6.71 0.00185 2.84 0.00225 8.58 0.00001 5.74 0.01571
hsa‐miR‐409‐3p 0.98 0.08592 −0.61 0.28229 0.74 0.19500 −1.59 0.00602 −0.24 0.66902 1.35 0.01930
hsa‐miR‐3688‐3p 0.51 0.57958 1.91 0.06064 7.49 0.00049 1.40 0.16211 6.98 0.00155 5.58 0.02543
hsa‐miR‐4741 1.47 0.28966 −2.17 0.21178 −5.49 0.00111 −3.64 0.03514 −6.96 0.00008 −3.32 0.02750
hsa‐miR‐197‐5p −1.78 0.07627 −0.91 0.38254 −3.09 0.00359 0.87 0.36925 −1.31 0.17164 −2.18 0.03232
hsa‐miR‐4656 0.00 1.00000 0.00 1.00000 −5.38 0.01415 0.00 1.00000 −5.38 0.00918 −5.38 0.03401
hsa‐miR‐539‐5p 0.88 0.23262 −1.40 0.05622 0.23 0.76622 −2.28 0.00249 −0.65 0.40096 1.63 0.03479
hsa‐miR‐4669 −1.18 0.23694 0.47 0.66589 5.92 0.01592 1.65 0.12971 7.10 0.00176 5.45 0.03707
hsa‐miR‐487b‐3p 0.81 0.20689 −1.03 0.10723 0.29 0.65768 −1.84 0.00490 −0.52 0.41977 1.32 0.04349
hsa‐miR‐32‐5p 1.18 0.07970 1.40 0.04207 2.92 0.00014 0.22 0.74798 1.73 0.02074 1.52 0.04563
hsa‐miR‐3168 −1.61 0.08382 −1.52 0.11232 −3.32 0.00070 0.09 0.91904 −1.71 0.05189 −1.80 0.04747
hsa‐miR‐127‐3p 0.67 0.23946 −0.86 0.13218 0.27 0.63184 −1.53 0.00829 −0.40 0.48431 1.13 0.04883
hsa‐miR‐3200‐3p −0.54 0.42913 0.74 0.28573 2.30 0.00370 1.28 0.06604 2.84 0.00036 1.56 0.05016
hsa‐miR‐1226‐5p 0.00 1.00000 −2.41 0.20171 −6.16 0.00363 −2.41 0.17430 −6.16 0.00200 −3.75 0.05919
hsa‐miR‐431‐5p 0.88 0.15574 −0.83 0.17949 0.32 0.60413 −1.72 0.00671 −0.56 0.37086 1.16 0.06627
hsa‐miR‐3176 0.39 0.64896 0.98 0.27615 3.28 0.00720 0.59 0.50588 2.89 0.01766 2.30 0.06791
hsa‐miR‐96‐5p 0.10 0.90504 3.08 0.00478 0.93 0.34204 2.98 0.00600 0.82 0.39365 −2.15 0.07055
hsa‐miR‐323b‐3p 1.04 0.09867 −0.96 0.12592 0.17 0.78606 −2.00 0.00186 −0.87 0.16990 1.13 0.07450
hsa‐miR‐134‐5p 0.46 0.42993 −1.59 0.00792 −0.54 0.36132 −2.05 0.00072 −1.00 0.09112 1.05 0.07512
hsa‐miR‐6817‐3p 2.34 0.14746 −0.81 0.65359 −3.91 0.02720 −3.16 0.07749 −6.26 0.00112 −3.10 0.07989
hsa‐miR‐3675‐5p −1.79 0.24878 −5.27 0.00953 0.00 1.00000 −3.48 0.04572 1.79 0.54421 5.27 0.08191
hsa‐miR‐101‐5p −0.26 0.71269 1.98 0.00902 3.70 0.00011 2.24 0.00323 3.96 0.00003 1.72 0.08236
hsa‐miR‐215‐5p −0.69 0.32213 1.32 0.07211 0.00 0.99959 2.01 0.00655 0.69 0.34299 −1.32 0.08442
hsa‐miR‐6087 −0.82 0.20554 0.94 0.15914 −0.21 0.75576 1.76 0.00870 0.62 0.34695 −1.14 0.09072
hsa‐miR‐379‐5p 0.37 0.54712 −1.79 0.00436 −0.78 0.20433 −2.16 0.00067 −1.15 0.06316 1.01 0.10252
hsa‐miR‐186‐3p −0.27 0.70727 2.04 0.01009 0.69 0.37896 2.31 0.00344 0.96 0.21567 −1.35 0.10372
hsa‐miR‐144‐3p −0.21 0.70470 0.53 0.33695 1.43 0.01089 0.74 0.18196 1.64 0.00372 0.90 0.10491
hsa‐miR‐362‐5p −0.38 0.71589 1.64 0.17067 6.14 0.01375 2.02 0.08769 6.52 0.00701 4.50 0.11413
hsa‐miR‐382‐5p 0.20 0.73529 −1.71 0.00398 −0.79 0.17501 −1.91 0.00141 −0.99 0.09144 0.92 0.11452
hsa‐miR‐93‐5p 0.21 0.70737 0.74 0.17907 1.58 0.00522 0.54 0.33068 1.37 0.01468 0.83 0.13379
hsa‐miR‐576‐5p 0.58 0.41817 1.19 0.10990 2.42 0.00401 0.61 0.40736 1.84 0.02733 1.23 0.14897
hsa‐miR‐654‐5p 0.05 0.93377 −1.79 0.00711 −0.85 0.19904 −1.85 0.00531 −0.90 0.16897 0.94 0.14940
hsa‐miR‐186‐5p −0.15 0.78205 1.58 0.00543 0.79 0.16078 1.74 0.00239 0.94 0.09432 −0.80 0.15387
hsa‐miR‐193b‐3p −0.46 0.65282 2.39 0.05210 6.46 0.00723 2.84 0.01896 6.91 0.00284 4.07 0.16243
hsa‐miR‐493‐5p 0.55 0.36327 −1.21 0.04985 −0.40 0.51433 −1.76 0.00472 −0.95 0.12077 0.81 0.18626
hsa‐miR‐183‐5p −0.13 0.82428 1.53 0.00798 0.79 0.16261 1.66 0.00423 0.92 0.10662 −0.74 0.19450
hsa‐miR‐9‐5p 0.80 0.25104 −0.69 0.32167 −1.57 0.02605 −1.49 0.03314 −2.37 0.00092 −0.88 0.20336
hsa‐miR‐4532 −0.35 0.55131 1.75 0.00339 1.08 0.06821 2.10 0.00052 1.42 0.01669 −0.68 0.24933
hsa‐miR‐124‐3p 1.71 0.25311 −0.63 0.67105 −2.34 0.11166 −2.34 0.13531 −4.05 0.01000 −1.71 0.24997
hsa‐miR‐20b‐5p 0.36 0.56185 1.43 0.02227 2.16 0.00093 1.08 0.08313 1.81 0.00518 0.73 0.25272
hsa‐miR‐144‐5p 0.64 0.29544 1.60 0.00999 2.31 0.00035 0.97 0.11459 1.67 0.00825 0.71 0.25844
hsa‐miR‐18b‐5p 0.09 0.91441 2.57 0.00663 1.39 0.15476 2.49 0.00836 1.30 0.18066 −1.19 0.27704
hsa‐miR‐29c‐3p −0.32 0.59801 1.45 0.02253 0.77 0.22160 1.77 0.00555 1.09 0.08311 −0.68 0.28407
hsa‐miR‐1908‐3p −1.32 0.16448 −2.21 0.02439 −3.11 0.00195 −0.88 0.31677 −1.78 0.04769 −0.90 0.31923
hsa‐miR‐16‐5p 0.81 0.13559 2.23 0.00008 1.73 0.00192 1.41 0.01047 0.92 0.09373 −0.50 0.35897
hsa‐miR‐3135b −1.52 0.08229 −2.56 0.00473 −1.79 0.05810 −1.04 0.21765 −0.27 0.76138 0.77 0.39688
hsa‐miR‐1299 2.64 0.00043 2.40 0.00149 3.07 0.00029 −0.24 0.74745 0.43 0.61108 0.66 0.43638
hsa‐miR‐432‐5p 0.37 0.51302 −1.24 0.03080 −0.83 0.14741 −1.61 0.00545 −1.20 0.03706 0.41 0.46475
hsa‐miR‐4488 −1.27 0.05904 −2.53 0.00028 −2.05 0.00300 −1.26 0.05394 −0.79 0.23068 0.48 0.46720
hsa‐miR‐550a‐3p 0.34 0.60175 1.76 0.00992 2.23 0.00189 1.42 0.03573 1.89 0.00792 0.47 0.51269
hsa‐miR‐106b‐5p 0.12 0.83321 1.84 0.00226 2.20 0.00033 1.72 0.00422 2.08 0.00066 0.37 0.53731
hsa‐miR‐15b‐5p 0.77 0.20034 1.33 0.02926 1.69 0.00661 0.56 0.35178 0.92 0.13351 0.35 0.56058
hsa‐miR‐194‐5p 0.46 0.48101 1.65 0.01576 2.04 0.00437 1.18 0.07923 1.58 0.02592 0.40 0.57754
hsa‐miR‐4466 −1.86 0.03462 −2.64 0.00372 −3.10 0.00092 −0.78 0.33855 −1.24 0.13824 −0.46 0.58416
hsa‐miR‐323a‐3p 0.73 0.24902 −1.17 0.06692 −0.86 0.18003 −1.90 0.00343 −1.59 0.01425 0.31 0.62297
hsa‐miR‐5189‐3p −4.27 0.00756 −2.05 0.23291 −2.84 0.13676 2.22 0.12249 1.43 0.35910 −0.79 0.65950
hsa‐miR‐490‐5p −0.89 0.33800 −2.97 0.00172 −2.61 0.00769 −2.09 0.01553 −1.72 0.05496 0.37 0.67376
hsa‐miR‐3138 −0.77 0.28981 −1.74 0.01899 −2.00 0.00831 −0.97 0.17370 −1.23 0.09157 −0.26 0.72111
hsa‐miR‐192‐5p −0.27 0.62776 1.41 0.01426 1.27 0.02673 1.68 0.00368 1.54 0.00750 −0.14 0.80729
hsa‐miR‐185‐5p −0.35 0.53115 1.56 0.00621 1.65 0.00391 1.91 0.00092 2.00 0.00055 0.09 0.86978
hsa‐miR‐3200‐5p 0.18 0.79454 2.51 0.00123 2.63 0.00161 2.33 0.00249 2.45 0.00314 0.12 0.88698
hsa‐miR‐15a‐5p 0.65 0.24229 1.46 0.01017 1.53 0.00692 0.80 0.14993 0.88 0.11489 0.08 0.88829
hsa‐miR‐451a 0.58 0.28405 2.56 0.00001 2.61 0.00001 1.98 0.00043 2.03 0.00030 0.06 0.91812
hsa‐miR‐3161 2.24 0.09828 5.79 0.00668 5.79 0.03406 3.55 0.11453 3.55 0.25406 0.00 1.00000
hsa‐miR‐217 −5.31 0.00585 0.00 1.00000 0.00 1.00000 5.31 0.01905 5.31 0.06827 0.00 1.00000