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. 2021 Jun 4;20(7):e13388. doi: 10.1111/acel.13388

FIGURE 2.

FIGURE 2

Capillary‐like microvascular network formation defects in HGPS iPSC‐ECs. (a) Matrigel‐based tube formation assay to assess the angiogenic activity of normal and HGPS iPSC‐ECs (scale bars = 200 μm). (b) Quantification of tube length per field. (c) Matrigel‐based tube formation assay to assess vascular network formation activity of HUVECs transduced with GFP‐control, GFP‐lamin A, or GFP‐progerin lentiviral vectors after 18 h (scale bars = 100 μm top, 200 μm bottom). (d) Quantification of tube length per field. ECs, endothelial cells; GFP, green fluorescent protein; LA, lamin A; Pg, progerin; HUVECs, human umbilical vein endothelial cells. Data are presented mean ±SEM, ***p < 0.0001; n, nine fields per group