Video 3.
Animation showing a morph of the atomic models produced by Namdinator for component 1 from the 3-D variability analysis of the SP4 dataset. Related to Fig. S13. These objectively built structures show the transition from the symmetric holo state to the asymmetric apo state, including bending of the CTD relative to the TMD and bending of M2 and M5 helices. Residues surrounding Zn site A (Asp47, Asp51, His155, and Asp159) are shown as simple sticks with elemental coloring; L154 and L199 representing the hydrophobic gate are shown in ball and stick representation in light and dark green colors, respectively.