Table 2.

Time-to-Event Analysis of Incidence and Mortality of Bloodstream Infection in the General Population by rs4957796 Genotype

					TC		CC		Additive
	Number of Patients	Time at Risk (years)	Number of Events	Incidence Rate per 100 000	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
Incidence of BSI
Any	69 294	1 140 218	2 698	236.6	0.99 (.91–1.08)	.829	1.20 (1.00–1.43)	.050	1.03 (.97–1.10)	.347
Gram-negative	69 294	1 140 218	1 537	134.8	0.95 (.85–1.06)	.380	1.28 (1.02–1.61)	.034	1.02 (.94–1.12)	.602
Gram-positive	69 294	1 140 218	1 161	101.8	1.04 (.92–1.18)	.497	1.08 (.81–1.44)	.589	1.04 (.94–1.16)	.403
Streptococcus pneumoniae	69 294	1 140 218	285	25.0	0.80 (.61–1.04)	.102	1.32 (.79–2.20)	.281	0.95 (.77–1.17)	.641
Staphylococcus aureus	69 294	1 140 218	323	28.3	1.24 (.99–1.56)	.062	0.65 (.32–1.32)	.237	1.07 (.88–1.29)	.504
Enterococcus faecalis	69 294	1 140 218	106	9.3	0.91 (.60–1.40)	.679	1.10 (.44–2.73)	.833	0.97 (.69–1.37)	.876
Escherichia coli	69 294	1 140 218	775	68.0	0.93 (.80–1.09)	.394	1.27 (.92–1.75)	.147	1.01 (.89–1.14)	.903
Mortality from BSI in total population
Any	69 372	1 154 745	444	38.5	0.77 (.62–.95)	.014	0.63 (.36–1.10)	.107	0.77 (.64–.92)	.004
Gram-negative	69 372	1 154 745	217	18.8	0.76 (.56–1.03)	.073	0.81 (.40–1.64)	.555	0.80 (.62–1.04)	.090
Gram-positive	69 372	1 154 745	225	19.5	0.75 (.56–1.01)	.060	0.47 (.19–1.15)	.098	0.72 (.55–.93)	.012

Abbreviation: BSI, bloodstream infection; CI, confidence interval; HR, hazard ratio.

First event and last event are used for incidence and mortality, respectively. Mortality defined as death within 30 days of BSI. All analyses are Cox proportional hazards analyses adjusting for age at first HUNT participation, sex, and first 5 ancestry-informative principal components. The analyses compare genotype group to TT or the effect of each additional C allele (using dosages).